Department of Biostatistics /
Epidemiology and Preventive Health Sciences,
School of Health Sciences and Nursing, University of Tokyo

• Welcome
• Teaching Staff
• Courses
• Doctoral Dissertations and Master's theses in 1999-2000
• Research Project
• Publications
• Main International Activities
• Lectures by Invited Foreign Scholars
• Access

Welcome

Welcome to the Web site of The Department of Biostatistics / Epidemiology and Preventive Health Sciences, University of Tokyo.

Yasuo OHASHI

Takuhiro YAMAGUCHI

Yoichi ITO

Graduate Courses

• BiostatisticsI,II (2 credits,2 credits) Prof. Ohashi and staff These courses aim to introduce and discuss recent progress in biostatistical methodology. These courses are given in a seminar-style and the materials are chosen from recently published advanced textbooks and expository/research papers. Students taking part in this seminar are expected to have basic knowledge on biostatistics and epidemiology. Topics recently discussed and to be discussed include design and analysis of clinical trials in oncology, longitudinal data analysis, categorical data analysis and Bayesian methods.
• Epidemiology and Preventive Health Sciences I (2 credits) Assoc.Prof. Hashimoto This course aims to introduce and discuss recent progress in epidemiological methodology. This course is given in a seminar-style and the materials are chosen from recently published advanced textbooks and expository/research papers.
• Epidemiology and Preventive Health Sciences II (2 credits) Assoc.Prof. Hashimoto Design and interpretation of some topics in epidemiology such as cancer, cardiovascular disease and pharmacoepidemiology are discussed for providing practical skills and concepts of epidemiology.

Undergraduate Courses

• Required Courses Epidemiology and Biostatistics (2 credits, lectures) Prof. Ohashi and Assoc. Prof. Hashimoto This course provides basic principles and concepts of epidemiology and biostatistics and covers the following items: introduction of epidemiology, introduction of biostatistics, variation and reliability of medical data, indices of health status and disease occurrence, standardization of indices, sensitivity and specificity of diagnostic tests, evaluation of risk/effects of intervention, basic statistical inference, bias and confounding, methodology of medical research, and utilization of health statistics.
• Statistical Methods and Information Processing (2 credits, practice) Prof. Ohashi, Staff and Affiliates As a simulation of medical research, randomized trials or case-control studies are conducted in a collaborative way. Through this practice (planning, protocol development, execution, data analysis, reporting), students learn basic concepts and skills of information retrieval, critical reading of research papers, protocol development, computer utilization, and data analysis/processing using SAS.

Elective Courses

• Applied Mathematics (2 credits, lectures) Prof. Ohashi Some topics of probability theory and matrix algebra are discussed for providing basic mathematical skill and concepts which are required for understanding methodological details of medical statistics, especially, linear models and multivariate analysis.
• Design and Analysis of Epidemiological Research (2 credits, lectures) Prof. Ohashi, Staff and Affiliates Methodological aspects of design and statistical analysis of epidemiological (or clinical) studies are discussed through critical review of research papers or review of specific research fields: the topics discussed include (1) asthma death and beta-agonists (pharmacoepidemiology), (2) passive smoking and lung cancer (risk assessment), (3) cholesterol lowering experiments (large scale clinical trial), (4) nutrition epidemiology, (5) air pollution(environmental epidemiology).
• Medical Data Analysis (3 credits, lectures and practice) Prof. Ohashi, Staff and Affiliates Lectures on statistical methods frequently used in medical literature are provided with practice in the PC-SAS environment. The methods covered are: (1) comparison of 2 groups, (2) correlation and regression, (3) analysis of variance (including repeated measurements analysis), (4) categorical data analysis (Mantel-Haenszel approach, logistic regression), and (5) survival analysis (Kaplan-Meier estimate, log-rank test, Cox regression).

Doctor

1999

• Oishi, T. Development of the disease-specific health related quality of life instrument for Japanese patients with diabetes mellitus. (Prof. Ohashi, Y.)
• Sato, K. The importance of the information disclosure and development of methods to provide medical information for participants in clinical trials -Developing and evaluating documents for providing medical information supporting cancer patients-. (Prof. Ohashi, Y.)

Master

2000

• Ando, T. Some issues in expanded Cox type regressions for recurrent events -in Applying to multiple sclerosis trials-. (Prof. Ohashi, Y.)
• Ito, Y. Parameter estimation for item response theory in quality of life questionnaires. (Prof. Ohashi, Y.)
• Kawado, M. Study on validation of data entry: Registry of kidney transplantation as an example. (Prof. Ohashi, Y.)
• Saito, Y. Quality of life of patients with advanced pancreatic cancer. (Prof. Ohashi, Y.)
• Wang, L. Case-control study of risk factors for development of type 2 diabetes: Emphasis on physical activity. (Prof. Ohashi, Y.)

• Biostatistics and Theoretical Epidemiology (by Dept. of B./E.P.) The aim of this project is to develop biostatistical and epidemiological methodology for designing clinical/epidemiological research and analyzing data. Recent topics include: survival data analysis, analysis of pharmacokinetic data, the random effect model and the computer intensive Bayesian approach. Many research projects involving data analysis are carried out with the collaboration of clinical researchers in a variety of clinical fields such as cancer, diabetes and vascular diseases.
• Methodology and Information Systems for Clinical Trials (by Dept. of B./E.P.) This project aims at developing statistical methodology for the design and analysis of clinical trials, especially early stage cancer clinical trials and prolonged large scale randomized trials. This project also tries to conduct fundamental research for establishing efficient and reliable information systems. Recently we started a series of research or QOL assessment including development of scales, validity study and comparison of scales.
• Health Care Data Management and Data Processing (by Dept. of B./E.P.) With the increasing activities of health sciences and the prevalence of computers, more and more health care data have become available in machine readable forms. This research project aims at the development of the health care data management and processing methodology, including health care data coding, health care data processing, information systems for health care research and ones for information retrieval.
• Descriptive Epidemiology and its Application (by Dept. of B./E.P.) The purpose of this project is to describe the distribution and trend of health-related states including AIDS and intractable diseases. Main sources of information are vital and health statistics.
• Pharmacoepidemiology (by Dept. of B./E.P.) The objective of pharmacoepidemiology is an assessment of benefits/risks of drugs by using epidemiologic approaches. Because of the rare occurrences of adverse effects, the utilization of established data-bases and record linkage techniques are expected to be useful tools for research. We have established a system (J-PEM) of data collection on the benefits/risks of drugs similar to Prescription Event Monitoring (PEM) in U.K. with the collaboration of the department of Pharmacoepidemiology.

Biostatistics and Theoretical Epidemiology (by Dept. of B./E.P.)

• Takahara S, Ota K, Ohashi Y, Namii Y, Uchida K, Kainuma H, Takagi H, Takahashi K, Morikawa H. Double blind comparative pharmacokinetic study of ciclosporin MEPC in stable renal transplantation patients. Transplantation Now 1999; 12(Suppl.); 5-24. (in Japanese)
• Ohashi Y. Drug development and biostatistics (1). Human Science 1999; 10(3): 14-17. (in Japanese)
• Ohashi Y. Drug development and biostatistics (2). Human Science 1999; 10(4): 13-17. (in Japanese)
• Ohashi Y. Drug development and biostatistics (3). Human Science 1999; 10(5): 10-15. (in Japanese)
• Kotake T, Usami M, Akaza H, Koiso K, Homma Y, Kawabe K, Aso Y, Orikasa S, Shimazaki J, Isaka S, Yoshida O, Hirao Y, Okajima E, Naito S, Kumazawa J, Kanetake H, Saito Y, Ohi Y, Ohashi Y, the Zoladex Study Group. Goserelin acetate with or without antiandrogen or estrogen in the treatment of patients with advanced prostate cancer: A multicenter, randomized, controlled trial in Japan. Japanese Journal of Clinical Oncology 1999; 29(11): 562-570.
• Furuse K, Kawahara M, Nishiwaki Y, Fukuoka M, Takada M, Miyashita M, Ohashi Y. Phase I/II Study of vinorelbine, mitomycin, and cisplatin for stage �VB or �W non-small-cell lung cancer. Journal of Clinical Oncology 1999; 17(10): 3195-3200.
• Hinotsu S, Akaza H, Kotake T, Ohashi Y. Intravesical chemotherapy for maximum prophylaxis of new early phase superficial bladder carcinoma treated by transurethral resection: A combined analysis of trials by the Japanese Urological Cancer Research Group using smoothed hazard function. Cancer 1999; 86(9): 1818-1826.
• Fujiwara K, Kohno I, Tanaka K, Ogita S, Sasaki Y, Hirabayashi K, Yakushiji M, Tsunematsu R, Terashima Y, Taguchi T, Ohashi Y, Noda K. PhaseIIdose escalation: A novel approach to balancing efficacy and toxicity of anticancer agents. Anticancer Research 1999; 19: 639-644.
• Sakamoto J, Hamada C, Kodaira S, Nakazato H, Ohashi Y. Adjuvant therapy with oral fluoropyrimidines as main chemotherapeutic agents after curative resection for colorectal cancer: Individual patient data meta-analysis of randomized trials. Japanese Journal of Clinical Oncology 1999; 29(2): 78-86.
• Saji T, Sakamoto J, Teramukai S, Kunieda K, Sugiyama Y, Ohashi Y, Nakazato H. Impact of splenectomy and immunochemotherapy on survival following gastrectomy for carcinoma: Covariate interaction with immunosuppressive acidic protein, a serum marker for the host immune system. Japanese Journal of Surgery 1999; 29: 504-510.
• Matsui S, Ohashi Y. Analysis of recurrent events: application to a clinical trial of colony stimulating factor with the endpoint of febrile neutropenia. Statistics in Medicine 1999; 18: 2409-2420.
• Hiraga K, Ohashi Y. Efficacy evaluation of analgesic agents used for cancer pain management by visual analogue scale. Pain Research 1999; 14(1): 9-19.
• Okada S, Sakata Y, Matsuno S, Kurihara M, Sasaki Y, Ohashi Y, Taguchi T. Phase II study of docetaxel in patients with metastatic pancreatic cancer: A Japanese cooperative study. British Journal of Cancer 1999; 80(3/4): 438-443.
• Akakura K, Isaka S, Akimoto S, Ito H, Okada K, Hachiya T, Yoshida O, Arai Y, Usami M, Kotake T, Tobisu K, Ohashi Y, Sumiyoshi Y, Kakizoe T, Shimazaki J. Long-term results of a randomized trial for the treatment of stages B2 and C prostate cancer: Radical prostatectomy versus external beam radiation therapy with a common endocrine therapy in both modalities. Urology 1999; 54(2): 313-318.
• Imamura H, Shimada R, Kubota M, Matsuyama Y, Nakayama A, Miyagawa S, Makuuchi M, Kawasaki S. Preoperative portal vein embolization: An audit of 84 patients. Hepatology 1999; 29: 1099-1105.
• Imamura H, Matsuyama Y, Miyagawa Y, Ishida K, Shimada R, Miyagawa S, Makuuchi M, Kawasaki S. Prognostic significance of anatomical resection and des-γ-carboxy prothrombin in patients with hepatocellular carcinoma. British Journal of Surgery 1999; 86(8): 1032-1038.
• Sakamoto J, Matsuyama Y, Ohashi Y. An analysis of the institutional effects in a multicenter cancer clinical trial- Is it also plausible from the clnicians' point of view-. Japanese Journal of Clinical Oncology 1999; 29(8): 403-405.
• Kiyonobu K, Osanai A, Azuma A, Kanda Y, Saito Y, Matsumura A, Numabe Y, Kamoi K, Noguchi K, Watanabe H, Ishikawa I, Matsuyama Y, Ohashi Y, Mishima A. Inter- and intra-examiner relaibility of clinical parameters used in periodontics. Journal of the Japanesse Society of Periodontology 1999; 41: 144-152. (in Japanese)
• Yamaguchi T, Ohashi Y. Investigating centre effects in a multi-centre clinical trial of superficial bladder cancer. Statistics in Medicine 1999; 18; 1961-1971.
• Mori Y, Kim-Motoyama H, Ito Y, Katakura T, Yasuda K, Ishiyama-Shigemoto S, Yamada K, Akanuma Y, Ohashi Y, Kimura S, Yazaki Y, Kadowaki T. The Gln27Glu β2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men. Biochemical and Biophysical Research Communications 1999; 258: 138-140.
• Koseki N, Araie M, Yamagami J, Shirato S, Yamamoto S. Effects of oral brovincamine on visual field damage in patients with normal-tension glaucoma with low-normal intraocular pressure. Journal of Glaucoma 1999; 8: 117-123.
• Shinohara H, Yumino K, Kishimoto J. Analysis of qualitative data in Educational Psychology. The Annual Report of Educational Psychology in Japan 1999; 38: 14-17. (in Japanese)
• Sato C, Hasebe Y. Instructive consideration for students preparing their theses. Quality Nursing 1999; 5(1): 40-44. (in Japanese)
• Hasebe Y, Nakayama E, Sato C. Effect of warm compress on thermal comfort sensation, body temperature, and cutaneous blood flow while turning in bed. Journal of Japanese Society of Nursing Research 1999; 22(5): 37-45. (in Japanese)
• Masaoka T, Hasegawa H, Takaku F, Mizoguchi H, Asano S, Ikeda Y, Urabe A, Shibata A, Saito H, Okuma M, Horiuchi A, Saito Y, Ozawa K, Usami M, Ohashi Y. The efficacy of intravenous immunoglobulin in combination therapy with antibiotics for severe infections. Japanese Journal of Chemotherapy 2000; 48(3): 199-217.
• Ohashi Y. Introduction of survival analysis. Statistics for Clinical Oncologists 2000; Booklet Series No.1. (in Japanese)
• Ohashi Y. Statistics for clinical research: Basic concepts and mathematics 1. Statistics for Clinical Oncologists 2000; Booklet Series No.2. (in Japanese)
• Togawa A, Mizoguchi H, Toyama K, Urabe A, Ohashi Y, Takaku F. Clinical evaluation of rhG-CSF in patients with neutropenia induced by chemotherapy for multiple myeloma. Japanese Journal of Clinical Hematology 2000; 41(2): 115-122. (in Japanese)
• Sakamoto J, Hamada C, Kato J, Kodaira S, Yasutomi M, Nakazato H, Ohashi Y. Evaluation of adjuvant therapy for colorectal cancer using meta-analyses of randomized trials. The Journal of the Japan Society of Colo-Proctology 2000; 53(10): 1008-1017. (in Japanese)
• Takiguchi K, Ishihara H, Ohashi Y, Kosaka K, Hayashi Y, Arakawa Y, Kikuchi M. Escalating dose study of a novel non-SU agent, A-4166, in type 2 diabetes. The Nihon University Journal of Medicine 2000; 42(1): 31-45.
• Ohno R, Yamaguchi Y, Toge T, Kinouchi T, Kotake T, Shibata M, Kiyohara Y, Ikeda S, Fukui I, Gohchi A, Sugiyama Y, Saji S, Hazama S, Oka M, Ohnishi K, Ohashi Y, Tsukagoshi S, Taguchi T. A dose-escalation and pharmacokinetics study of subcutaneously administered recombinant human interleukin 12 and its biological effects in Japanese patients with advanced malignancies. Clinical Cancer Research 2000; 6: 2661-2669.
• Gotoh F, Ohashi Y, the Cilostazol stroke prevention study group. Design and organization of the Cilostazol stroke prevention study. Journal of Stroke and Cerebrovascular Diseases 2000; 9(1): 36-44.
• Yasuda K, Ohashi Y, Matsushima T, Kumada H, Hino K, Ito M, Takeuchi T, Kakumu S, Kuroki T, Hayashi N, Sata M, Iino S. Low-dose oral interferon-α in the treatment of chronic viral hepatitis type B: A double-blind, randomized, placebo-controlled, clinical trials. Current Therapeutic Research 2000; 61(5): 245-254．
• Takayama T, Sekine T, Makuuchi M, Yamasaki S, Kosuge T, Yamamoto J, Shimada K, Sakamoto M, Hirohashi S, Ohashi Y, Kakizoe T. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial. The Lancet 2000; 356: 802-807．
• Yokoyama H, Okudaira M, Otani T, Sato A, Miura J, Takaike H, Yamada H, Muto K, Uchigata Y, Ohashi Y, Iwamoto Y. Higher incidence of diabetic nephropathy in type 2 than in type 1 diabetes in early-onset diabetes in Japan. Kidney International 2000; 58: 302-311.
• Akaza H, Homma Y, Okada K, Yokoyama M, Moriyama N, Usami M, Hirao Y, Tsushima T, Ohashi Y, Aso Y, the Prostate Cancer Study Group. Early results of LH-RH agonist treatment with or without chlormadinone acetate for hormone therapy of naive localized or locally advanced prostate cancer: A prospective and randomized study. Japanese Journal of Clinical Oncology 2000; 30(3): 131-136.
• Sato T, Matsuyama Y. Biostatistics in medical research. Molecular Cancer Therapeutics 2000; 1(1): 70-75. (in Japanese)
• Matsuyama Y, Sato T. The design of clinical studies: Randomized Clinical trials. Molecular Cancer Therapeutics 2000; 1(2): 163-168. (in Japanese)
• Taguchi T, Hasebe Y, Yamanaka Y, Takehisa H, Nakayama E, Sato C, Akiba T, Marumo F, Kurihara R, Ogasawara M. Support for hemodialysis patients considering traveling. Journal of Japanese Society for Dialysis Therapy 2000; 33(6): 1053-1058. (in Japanese)
• Nakayama E, Yamanaka Y, Takehisa H, Hasebe Y, Sato C. Investigation about hospital timetables for inpatients. The Japanese Journal of Nursing 2000; 19(9): 136-139. (in Japanese)

Methodology and Information Systems for Clinical Trials (by Dept. of B./E.P.)

• Niimi M, Takeshima H, Hinotsu A, Takahashi H, Kano K, Otani M, Ishikawa S, Noguchi R, Oda E, Ohashi Y, Akaza H. The critical appraisal of QOL questionnaire for prostate cancer patients. Japanese Journal of Cancer & Chemotherapy 1999; 26(3): 333-343. (in Japanese)
• Sato K. The debate over maternal-fetal HIV transmission prevention trials in developing countries. Clinical Evaluation 1999; 26(3): 381-386. (in Japanese)
• Sato K. The role of clinical research coordinator in clinical trials. Nurse Manager 1999; 1(5): 42-44. (in Japanese)
• Ohashi Y. Why we cannot conduct mega-trials in Japan? -future of clinical trial in Japan-. Clinic All-round 2000; 49(3): 433-435. (in Japanese)
• Morita S、Ohashi Y. QOL Evaluation in patients with advanced non-small-cell lung cancer (NSCLC). The Society for Clinical and Biostatistical Research on Cancer 2000; 20(1): 54-59. (in Japanese)
• Ohashi Y. How do we improve the infrastructure for clinical trials of drug in Japan? Japanese pharmacology and Therapeutics 2000; 28(4): 310-315. (in Japanese)

Descriptive Epidemiology and its Application (by Dept. of B./E.P.)

• Hayashi M, Hashimoto S, Kato M, Ojima T, Nakamura Y, Miyashita M, Fukutomi K. The importance of regional health and welfare indexes. Bulletin of Fukushima School of Nursing 1999; 33-48. (in Japanese)
• Hashimoto S, Miyashita M, Tsuji I. Methods of health expectancy. Journal of Health and Welfare Statistics 1999; 46(4): 12-16. (in Japanese)
• Miyashita M, Hashimoto S, Ojima T, Nakamura Y, Hayashi M, Kato M, Fukutomi K. Proportion of dependence and dependence-free expectancy in the elderly. Journal of Health and Welfare Statistics 1999; 46(5): 25-29. (in Japanese)
• Miyashita M, Hashimoto S, Kawa M, Kojima M. Attitudes towards terminal care among the general population and medical practitioners in Japan. Japanese Journal of Public Health 1999; 46: 391-401. (in Japanese)
• Matsumura Y, Nakamura Y, Hayashi M, Kato M, Miyashita M, Ojima T, Fukutomi K, Hashimoto S. Prefectural differences of smoking rates. Journal of Health and Welfare Statistics 1999; 46(6): 23-28. (in Japanese)
• Ishikawa K, Ohta T, Zhang J, Hashimoto S, Tanaka H. Influence of age and gender on exercise training-induced blood pressure reduction in systemic hypertension. American Journal of Cardiology 1999; 84(2): 192-196.
• Ohki I, Hashimoto S, Ichikawa S, Kamakura M, Kidokoro T, Kihara M, Kimura H, Kimura S, Matsuyama Y, Oka S, Umeda T, Fukutomi K, Nakamura Y. Trends in AIDS deaths based on vital statistics. Journal of Health and Welfare Statistics 1999; 46(8): 26-33. (in Japanese)
• Ojima T, Nakamura Y, Hashimoto S, Miyashita M, Hayashi M, Kato M, Matsumura Y, Fukutomi K. Development of area indices in health, medical and welfare. Journal of Health and Welfare Statistics 1999; 46(15): 3-9. (in Japanese)
• Murakami Y, Hashimoto S, Taniguchi K, Nagai M. Distributions of the numbers of monitaring stations in the survellance of infectious diseases in Japan. Japanese Journal of Public Health 1999; 46: 1060-1067. (in Japanese)
• Hashimoto S, Murakami Y, Taniguchi K, Nagai M. Determination of the numbers of monitaring medical institutions necessary for estimating incidence rates in the survellance of infectious diseases in Japan. Japanese Journal of Public Health 1999; 46: 1068-1076. (in Japanese)
• Matsuyama Y, Hashimoto S, Ichikawa S, Nakamura Y, Kidokoro T, Umeda T, Kamakura M, Kimura S, Fukutomi K, Ikeda C, Kihara M. Trends in HIV and AIDS based on HIV/AIDS surveillance data in Japan. International Journal of Epidemiology 1999; 28: 1149-1155.
• Sasaki M, Katagiri A, Maeda K. Nutrient intake levels of students in school of nutrition. Bulletin of Tokyo Kasei University 1999; 39: 31-37. (in Japanese)
• Katagiri A, Hashimoto S, Ohashi Y, Kanazawa Y. Diabetes education in public health centers in Kanto area. Journal of Health and Welfare Statistics, 1999; 46(13): 28-33. (in Japanese)
• Takahashi M, Shibazaki S, Hashimoto S, Kawakami N, Tamakoshi A, Ojima T, Nagai M. Evaluation of the operation of supporting programs for social activity of the elderly by city, town, village government in Japan. Japanese Journal of Public Health 2000; 47: 47-54. (in Japanese)
• Hashimoto S, Matsumoto T, Nagai M, Matsuyama Y, Nakamura Y, Umeda T, Kamakura M, Ichikawa S, Kimura S, Fukutomi K, Kihara M. Delays and continuation of hospital visits among HIV-infected persons and AIDS cases in Japan. Journal of Epidemiology 2000; 10(1): 65-70.
• Ichikawa S, Kimura S, Ohya H, Kimura H, Oka S, Itoh A, Masuda G, Hanabusa S, Sagara H, Hashimoto S, Kamakura M, Nakamura Y, Kihara M. A study on the medical care cost for people with HIV/AIDS in Japan. The Journal of AIDS Research 2000; 2: 22-29. (in Japanese)
• Hashimoto S, Fukutomi K, Ichikawa S, Matsuyama Y, Nakamura Y, Kihara M. Future prediction of the number of HIV-infected persons and AIDS cases. The Journal of AIDS Research 2000; 2: 35-42. (in Japanese)
• Ohno Y, Aoki R, Tamakoshi A, Kawamura T, Wakai K, Hashimoto S, Kawakami N, Nagai M. Successful Aging and social activity in older Japanese adults. Journal of Aging and Physical Activity 2000; 8: 129-139.
• Kato M, Hashimoto S, Miyashita M, Hayashi M, Nakamura Y, Ojima T, Matsumura Y, Fukutomi K. Geographic differences of welfare countermeasures for the elderly. Journal of Health and Welfare Statistics, 2000; 47(4): 8-13. (in Japanese)
• Hashimoto S, Murakami Y, Taniguchi K, Nagai M. Detection of epidemics in their early stage through infectious disease surveillance. International Journal of Epidemiology 2000; 29: 905-910.
• Murakami Y, Hashimoto S, Taniguchi K, Fuchigami H, Nagai M. Temporal and geographical variation in epidemics determined from the results of an infectious disease surveillance system in Japan: description of epidemic patterns by data-based criteria for epidemic periods. Japanese Journal of Public Health, 2000: 47: 925-935. (in Japanese)
• Takahashi M, Shibazaki S, Hashimoto S, Kawakami N, Tamakoshi A, Ojima T, Nagai M. Evaluation of social activities of the elderly in 27 regions with use of the 'check list for vivid social activities'. Japanese Journal of Public Health 2000; 47: 936-944. (in Japanese)
• Matsuyama Y, Hashimoto S, Ichikawa S, Nakamura Y, Kidokoro T, Fukutomi K, Kihara M. Trends in the number of death cases reported to the HIV/AIDS surveillance. The Journal of AIDS Research 2000; 2(1): 30-34. (in Japanese)
• Nakamura Y, Matsuyama Y, Kidokoro T, Umeda T, Oka S, Kimura H, Kamakura M, Ichikawa S, Hashimoto S, Fukutomi K, Kimura S, Kihara M. Epidemiologic features of HIV infection and AIDS in Japan estimated by the delphi methods: Data which cannot be obtained by usual epidemiologic surveys. The Journal of AIDS Research 2000; 2(2): 49-55. (in Japanese)
• Sasaki S, Tsuji T, Katagiri A, Shimoda T. Association between the number of food items bought in convenience stores and nutrient and food-group intakes -A survey of first-year female college students taking dietetic couses-. Journal of Japanese Society of Nutrition and Food Science 2000; 53(5): 215-226. (in Japanese)

B. Congress, Seminar, Workshop, etc.

• Ohashi Y, The 2nd Annual Japanese Symposium on Clinical Data Management: The Role of Data Managers in Quality Control and Data Integrity (Drug Information Association), Tokyo, Japan; 1999/1/25-6.
• Ohashi Y, The 1st US-Japan Workshop on Clinical Trials -For further development of cancer therapeutics-, Tokyo, Japan; 1999/2/8-10.
• Ohashi Y, Workshop on Statistical Methodology in Clinical R&D (Drug Information Association), Prague, Czech Republic; 1999/4/19-21.
• Ohashi Y, Hamada C, Sato K, Yamamoto S, The 35th Annual Meeting of American Society of Clinical Oncology, Atlanta, USA; 1999/5/15-8.
• Ohashi Y, Statistical Issues in Biopharmaceutical Environments: Toward the New Millennium, Leicester, UK; 1999/7/28-30.
• Ohashi Y, The 6th Annual Biostatistics Workshop (Drug Information Association), Tokyo, Japan; 1999/8/19-20.
• Ohashi Y, The Second Tokyo Forum of New Anticancer Drugs, Tokyo, Japan; 1999/8/27.
• Hashimoto S, The APA/NIOSH Conference on Work, Stress, and Health '99, Baltimore, USA; 1999/3/11-13, Kawakami N, Naratani T, Kobayashi F, Ishizaki M, Hayashi T, Fujita O, Aizawa Y, Miyazaki S, Hiro H.
• Hashimoto S, The Fifth International Congress on AIDS in Asia and the Pacific, Kuala Lumpur, Malaysia; 1999/10/23-27, Ichikawa S, Ohya H, Kihara M, Kihara M, Kimura H, Kamakura M, Kimura K, Nakamura Y.
• Ohashi Y, Hamada C, The 36th Annual Meeting of American Society of Clinical Oncology, New Orleans, USA; 2000/5/20-3.
• Ohashi Y, The 7th Annual Biostatistics Workshop (Drug Information Association), Tokyo, Japan; 2000/8/24-5.
• Ohashi Y, PhRMA (Pharmaceutical Research and Manufactures of America) 2000 Biostatistics and Data Management Workshop, Washington, USA; 2000/11/1-3.
• Ohashi Y, Second Seattle Symposium in Biostatistics: Analysis of Correlated Data, Seattle, USA; 2000/11/18-21.
• Ohashi Y, World Congress on Osteoporosis 2000, Chicago, USA; 2000/6/15-18, Watanabe H, Fukunaga M.
• Hashimoto S, Scientific Meeting on Palliative Care 2000, Jerusalem, Israel; 2000/5/19-32, Miyashita M, Imamura Y, Kawa M.
• Hashimoto S, The 8th International AIDS Conference, Durban, South Africa; 2000/7/9-14, Kihara M, Ichikawa S, Kihara M, Imai M, Wada K, Kumamoto Y, Shimizu M.
• Katagiri A, The 4th Congress of the International Society for the Study of Fatty Acids and Lipids (ISSFAL), Tsukuba, Japan; 2000/6/4-9, Sasaki S, Shimoda T, Tsuji T, Amano K.
• Katagiri A, Ohashi Y, The 60th Annual Meeting and Scientific Sessions, American Diabetes Association, San Antonio, USA; 2000/6/9-13, Sone H, Yamada N, Akanuma Y.
• Katagiri A, The 3rd Asian Conference on Food Safety and Nutrition, Beijing, China; 2000/10/3-6, Yoshiike N, Ichimura K, Iwaoka H, Ishida H, Nakamura M, Matsumura Y.
• Hinotsu S, Ohashi Y, American Urological Association, Atlanta, USA; 2000/5/2, Akaza H, Kotake T.
• Oishi T, Ohashi Y, The Seventh Annual Symposium of Contributed Papers: Quality of Life Evaluation, The Drug Information Association, Hilton Head SC, USA; 2000/4/2-4, Abe R.

• "Fitting Nonlinear and Generalized Linear Mixed Models using PROC NLMIXED" by Dr. Russell Wolfinger; SAS Institute Inc.; the Medical Library's Conference Room of the University of Tokyo; August 29, 2000 (by Dept. of Biostatistics / Epidemiology and Preventive Health Sciences)
• "Individual Bioequivalence" by Dr. Shein-Chung Chow; StatPlus, Inc. and Temple University, USA; the Medical Library's Conference Room of the University of Tokyo; November 9, 2000 (by Dept. of Biostatistics / Epidemiology and Preventive Health Sciences)

• Adress: Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
• Tel: +81-3-5841-3520 Fax: +81-3-3814-2779